Salvage of vascular graft infections via vacuum sealing drainage and rectus femo

Peng Zhang, Fu-Lin Tao, Qing-Hu Li, Dong-Sheng Zhou, Fan-Xiao Liu

Peng Zhang, Fu-Lin Tao, Qing-Hu Li, Dong-Sheng Zhou, Fan-Xiao Liu, Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021, Shandong Province, China

Abstract BACKGROUND The management of vascular graft infections continues to be a significant challenge in a clinical situation. The aim of this report is to illustrate the novel vacuum sealing drainage (VSD) technique and rectus femoris muscle flap transposition for vascular graft infections, and to evaluate the prospective of future testing of this surgical procedure.CASE SUMMARY We report the case of a 32-year-old male patient, who presented a severe infected groin wound with biological vascular graft Acinetobacter baumannii infection resulting in extensive graft exposure. Using the VSD and muscle flap transposition, the groin wound and vascular graft infection were finally treated successfully.CONCLUSION Our case report highlights that VSD technique and rectus femoris muscle flap transposition could be considered in patients presenting with a severe infected groin wound with biological vascular graft Acinetobacter baumannii infection resulting in extensive graft exposure, especially in consideration of treatable conditions.

Key Words: Vascular graft; Infection; Muscle flap transposition; Rectus femoris muscle flap; Vacuum sealing drainage; Case report; Trauma

INTRODUCTION

Vascular graft infection resulting from injury is a rare involving in the femoral region.It remains one of the most challenging complications in vascular trauma surgery. The gradual and irreversible deterioration of the vessel wall is the most serious issue on the conservative treatment of major vascular graft infections, significantly increasing bleeding risk[1-3].

Active wound treatment with vacuum sealing drainage (VSD) therapy is considered a very important strategy to accelerate wound healing and improve its prognosis[4,5].Several studies demonstrated the excellent performance in the use of muscle flaps for treating chronically wound beds infected with various pathogenic organisms[6-8].

In the presented study, we report a patient who suffered from a severe vascular graftAcinetobacter baumanniiinfection and was cured successfully by using VSD to cover the infected wound and the rectus femoris muscle flap transposition is reported to share our experience with vascular graft salvage in the treatment of peripheral vascular graft infections involving the groin.

CASE PRESENTATION

Chief complaints

Vascular graft infections for 2 wk.

History of present illness

A 32-year-old male patient was transferred to our hospital because of hip and lower limb injuries caused by heavy objects. The initial diagnosis was left femoral artery defect injury and lower limb injuries. The left femoral artery defect injury was treated by anastomosis with artificial vascular graft (approximately 10 cm in length) and lower limbs injuries were managed using femoral external fixation. After 14 d, a recurrent deep right wound developed, with an exposure of the artificial vascular graft at the distal anastomosis level and underlying tissue necrosis. His family history and past history had nothing notable.

History of past illness

The patient had no major trauma or damage to the blood vessels before.

Personal and family history

There is nothing special about the patient’s personal and family history.

Physical examination

In the physical examination, the external fixator was firmly fixed. An obvious severe inguinal infection and extensive exposure of an artificial vascular graft (approximately 3.5 cm in length) that was not embedded in the surrounding tissues, with underlying tissue necrosis, were observed. The peripheral sensation of the left lower limb was normal, the peripheral blood supply of left lower limb was good, and left dorsalis pedis artery and posterior tibial artery pulsation was touched.

Laboratory examinations

Repeated bacteriological cultures were positive forAcinetobacter baumannii.

Imaging examinations

The first computed tomography angiography was performed in another hospital,which revealed that the left femoral artery defect injury was repaired by anastomosis with an artificial vascular graft (Figure 1).

FINAL DIAGNOSIS

Based on imaging findings and the pathogenic microorganism identified, we finally diagnosed the patient with an obvious severe inguinal infection caused byAcinetobacter baumanniiand extensive exposure of the artificial vascular graft(approximately 3.5 cm in length) that was not embedded in the surrounding tissues.

TREATMENT

The artificial vascular graft was completely excised and the blood flow was unimpeded fortunately (Video). After initial debridement of the perivascular necrotic tissue, a continuous VSD device of 125 mmHg (17 kPa) was applied in the inguinal wound. A silicon-based dressing was used for coverage of the visible graft material and native artery in the wound; regular changes of the dressings were usually done in the ward (Figure 2).

OUTCOME AND FOLLOW-UP

Two weeks later, the wound was closed to protect both the anastomosis and the artificial vascular graft using rectus femoris muscle flap transposition. The large infected surgical wound was filled with a muscle flap adjacent to the biological graft and no bleeding was detected from both the anastomosis and the arterial wall. We did not add any antibiotic forAcinetobacter baumanniiinfection because of the antibiotic resistance. The muscle flap survived and the wound of the patient at risk healed successfully after 3 wk.

DISCUSSION

Vascular graft infection due to injury rarely involves the femoral region. It remains one of the most challenging complications in vascular trauma surgery. Local muscle flap transposition demonstrated the promising performance in the treatment of low-grade infections in the early stage but carried an unreasonable risk of failure in the highgrade infections sustained by high-virulence bacteria[1-3,5,9-11].

In our opinion, the careful analysis of patient’s medical history is particularly important. Infection occurring after the left femoral artery surgical revascularization,culture positivity forAcinetobacter baumanniiand methicillin-resistant species, and exposure of the arterial-graft anastomosis were poor prognostic indicators for graft preservation. Furthermore, the wound infection in the groin had exposed the anastomosis and failed prior debridement and antibiotic treatment. Moreover, due to the poor general condition of the wound infected byAcinetobacter baumannii, surgeries including VSD and muscle flap transposition were not conducted simultaneously.Several studies have revealed a significantly increased risk for graft infection in the groin when multiple repeated surgeries were conducted[12-14].

Figure 1 Computed tomography angiography. The left femoral artery defect injury was repaired by anastomosis with an artificial vascular graft.

Figure 2 A severe inguinal wound infected with Acinetobacter baumannii at 2 wk after surgery. The graft infection was treated by the vacuum sealing drainage (VSD) procedure (negative pressure wound therapy with 125 mmHg was commenced. A: Preoperative appearance; B: The graft was uncovered for a distance of 3.5 cm after the VSD procedure; C: The artificial graft was exposed in the right groin region and the wound revised by rectus femoris muscle flap transposition; D: The muscle flap survived and the wound of the patient at risk healed successfully after 3 wk.

Previous studies have reported many risk factors for vascular graft infections, such as groin incisions, wound infections, and comorbidities. A retrospective study[15]involving 39 of 438 patients with a vascular graft infection demonstrated that renal insufficiency, hemorrhage, incisional surgical site infections, and longer procedure time could increase the risk factor for vascular graft infections. A retrospective and descriptive study[16]including 223 patients receiving abdominal or lower extremity revascularization surgery identified risk factors for vascular graft infections and revealed that diabetes mellitus, hemoglobin A1c more than 7.0, blood glucose more than 180 mg/dL, and lack of mobility were preoperative risk factors; perioperative hypoxemia and hemostatic agents were intraoperative factors; admission to skilled nursing facility or acute rehabilitation facility and unscheduled clinic visits were postoperative factors. The warm, wet environment in the groin area combined with innumerable skin folds leads to a high burden of bacteria, which makes deep perivascular infected groin wounds particularly challenging to heal[17,18]. VSD strategy and graft preservation had been warned in case ofAcinetobacter baumanniiinfection and sepsis; however, the wound of our patient at risk healed successfully. In our case,the initial operation was conducted to reduce infection of the groin wound and vascular graft. Our surgical team had long-standing experience in the treatment of various wounds by using the VSD method, which can be useful in the prevention of peripheral arterial injury in certain challenging cases and in the development of a hybrid approach.

To our knowledge, active wound treatment with VSD therapy is considered a vital important modality to accelerate wound healing and improve prognosis. Selective adjunctive strategies including muscle flap coverage probably contributed to the cover of dead space, and a decreased time of wound healing and risk of recurrent infections[4]. The muscle flap combined with VSD therapy can be useful for speeding up wound healing[5].

Several studies demonstrated the excellent performance in the use of muscle flaps for treating chronically wound beds infected with various pathogenic organisms[6-8].These flaps have been shown to reduce healing time, lower wound bed bacterial count,improve antibiotic delivery, and obliterate dead space, thus decreasing the possibility of recurrent infection. In the present case, the muscle flap coverage was used for stable wound coverage regardless of the fate of the graft.

In addition to aggressive serial debridement and VSD, the rectus femoris muscle flap provided the best solution to promote healing of the infected field in this case.While the underlying mechanisms and biological effects of the muscle flap on the injured vessel wall remain to be proven, it is possible conduct trials with this technique to significantly improve limb salvage rates and avoid the related requirement to resort to extra-anatomic bypass, which carries high morbidity and mortality. In our opinion,with multidisciplinary treatment of malnutrition, infection, and local wound coverage along with the creative use of muscle flap closures, improved graft salvage rates and markedly increased limb salvage rates can be achieved.

CONCLUSION

This case highlights that VSD technique and rectus femoris muscle flap transposition could be considered in patients presenting with a severe infected groin wound withAcinetobacter baumanniibiological vascular graft infection resulting in extensive graft exposure, especially in consideration of treatable conditions.