氯雷他定在治疗小儿喘息性支气管炎中的疗效观察

米青+等

[摘要] 目的 探讨氯雷他定在治疗小儿喘息性支气管炎中临床疗效。 方法 将随机选取该院2010年1月—2014年5月儿科住院治疗的小儿喘息性支气管炎100例，随机分为对照组50例（常规治疗）；观察组50例（常规治疗+氯雷他定治疗），详细将两组患儿治疗前后外周血嗜酸性粒细胞、WBC、IL-2、4、5水平进行记录；两组患儿治疗过程中发热、咳嗽、咯痰、咽痛、胸片阳性缓解时间进行记录；两组患儿治疗后疗效比较进行记录分析。 结果 干预前，两组患儿的血WBC、IL-2、4、5水平比较，差异无统计学意义（P>0.05）；干预后，两组患儿的血WBC、IL-2、4、5水平均显著下降，观察组患者指标显著低于对照组患儿，差异有统计学意义（P<0.05）。观察组患儿治疗过程中发热、咳嗽、咯痰、咽痛、胸片阳性缓解时间显著低于对照组患儿，差异有统计学意义（P<0.05）。治疗7 d后，观察组患儿的临床总有效率98%，显著高于对照组78%，差异有统计学意义（P<0.05）。结论 氯雷他定可有效干预患儿WBC、嗜酸性粒细胞、IL-2、IL-4、IL-5水平，有效缩短患儿治疗时间，氯雷他定治疗治疗小儿喘息性支气管炎疗效确切。

[关键词] 氯雷他定；小儿；喘息性支气管炎；临床疗效

[中图分类号] R758.23 [文献标识码] A [文章编号] 1674-0742（2015）09（a）-0009-03

Observation of the Curative Effect of Loratadine in the Treatment of Asthmatic Bronchitis in Children

MI Qing1， JI Cun-dong2， CHEN Li-ping1， LI Xia1， QI Li-na1

1 Department of Pediatrics， Tai'an Central Hospital， Tai'an， Shandong Province， 271000 China；2. Emergency Department， Eighty-eighth PLA Hospital， Tai'an， Shandong Province， 271000 China

[Abstract] Objective To investigate the curative effect of Loratadine in the treatment of asthmatic bronchitis in children. Methods 100 children with asthmatic bronchitis hospitalized in Department of Pediatrics of our hospital from January 2010 to May 2014 were randomly divided into the control group and the observation group with 50 children in each. The control group was given conventional treatment， and the observation group was given Loratadine combined with conventional treatment. The levels of eosinophile granulocyte， WBC， IL-2， IL-4 and IL-5 in peripheral blood of the two groups were recorded in detail before and after treatment. The relief time of fever， cough， expectoration， sore throat， positive chest X-ray of the two groups during the treatment was recorded. And the efficacy of the two groups was recorded and analyzed and compared after treatment. Results After intervention， the level of WBC， IL-2， IL-4， IL-5 in both groups decreased significantly， moreover， that was much lower in the observation group than in the control group， respectively with statistically significant difference（P<0.05）. The relief time of fever， cough， expectoration， sore throat， positive chest X-ray during the treatment was much shorter in the observation group than that in the control group， respectively， with statistically significant difference（P<0.05）. After 7 d of treatment， The overall clinical response rate was much higher in the observation group than in the control group（98% vs 78%） with statistically significant difference（P<0.05）. Conclusion For children with asthmatic bronchitis， Loratadine can effectively improve the level of WBC， eosinophile granulocyte， IL-2， IL-4 and IL-5 levels and shorten the duration of treatment with exact curative effect.